Recently, PC Magazine reviewed and ranked antivirus software.  Here are the current Top Five:

1.  G-Data AntiVirus 2010
2.  Symantec Norton AntiVirus 2010
3.  Kaspersy Anti-Virus 2010
4.  BitDefender Antivirus 2010
5.  Panda Antivirus Pro 2010

It is worth noting that AVG and McAfee are not currently listed in the top 5.